*This clinical trial study was designated to evaluate the wound healing effect of Dragon's blood on human wounds. Sixty patients, between the ages of 14–65 years, who were referred to remove their skin tag, were assigned to this double-blind, placebo-controlled, randomized clinical trial and received either Dragon's blood or a placebo cream.

They were visited on the 3rd, 5th, 7th, 10th, 14th, and 20th day of the trial to check the process of healing and to measure the wound's surface. At the end of trial, there was a significant difference in the mean duration of wound healing between the two groups.

The phenolic compounds and the alkaloid taspine, which exist in Dragon's-blood resin, are probably the main reasons for the wound healing property of this plant. Being natural accessible, safe, and affordable makes Dragon's blood cream, a good choice for addition to the wound healing.

*This study used Croton lechleri which is another species of Dragons Blood.

Conclusions: This clinical trial suggests Dragon's blood is a potent, available, affordable, and safe healing agent. The exact role of Dragon's blood in the pathogenesis of wound healing regarding its effect on stimulation or hindering mediator's synthesis is still absent and further studies are required. Our study encourages evaluating the healing process on other wounds such as diabetic ulcers, bedsores, or burns.

Keywords: clinical trial, Dragon's blood, wound healing